disease (n.)
early 14c., "discomfort, inconvenience," from Old French desaise "lack, want; discomfort, distress; trouble, misfortune; disease, sickness," from des- "without, away" (see dis-) + aise "ease" (see ease). Sense of "sickness, illness" in English first recorded late 14c.; the word still sometimes was used in its literal sense early 17c.