exacerbation (n.) Look up exacerbation at Dictionary.com
c. 1400, from Late Latin exacerbationem (nominative exacerbatio), noun of action from past participle stem of Latin exacerbare "exasperate, irritate, provoke," from ex, here probably "thoroughly" (see ex-), + acerbus "harsh, bitter," from acer "sharp, keen," from PIE root *ak- "be sharp" (see acro-).