immune (adj.) Look up immune at
mid-15c., "free, exempt" (from taxes, tithes, sin, etc.), from Latin immunis "exempt from public service, untaxed; unburdened, not tributary," from assimilated form of in- "not, opposite of" (see in- (1)) + munis "performing services" (compare municipal), from PIE *moi-n-es-, suffixed form of root *mei- (1) "to change" (see mutable). Specific modern medical sense of "exempt (from a disease)," typically because of inoculation, is from 1881, a back-formation from immunity. Immune system attested by 1917.