molecule (n.) Look up molecule at Dictionary.com
1794, "extremely minute particle," from French molécule (1670s), from Modern Latin molecula, diminutive of Latin moles "mass, barrier" (see mole (3)). A vague meaning at first; the vogue for the word (used until late 18c. only in Latin form) can be traced to the philosophy of Descartes. First used of Modern Latin molecula in modern scientific sense by Amedeo Avogadro (1811).